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Gene: Crem (cAMP responsive element modulator) Rattus norvegicus
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Symbol: Crem
Name: cAMP responsive element modulator
Description: Predicted to have RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including glucose metabolic process; regulation of circadian rhythm; and retinoic acid receptor signaling pathway. Predicted to localize to the cytoplasm; nucleus; and transcription factor complex. Biomarker of transient cerebral ischemia. Orthologous to human CREM (cAMP responsive element modulator); INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP responsive element moderator; cAMP-responsive element modulator; CRE modulator; CREM delta C-G; CREM-17X; Icer; inducible cyclic AMP early repressor
Orthologs:
Homo sapiens (human) : CREM (cAMP responsive element modulator)  HGNC  Alliance
Mus musculus (house mouse) : Crem (cAMP responsive element modulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crem (cAMP responsive element modulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CREM (cAMP responsive element modulator)
Canis lupus familiaris (dog) : CREM (cAMP responsive element modulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crem (cAMP responsive element modulator)
Sus scrofa (pig) : CREM (cAMP responsive element modulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01757,021,704 - 57,090,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01755,055,678 - 55,122,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41762,770,633 - 62,837,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11762,793,252 - 62,846,993 (+)NCBI
Celera1750,219,777 - 50,286,184 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
RH 3.4 Map17555.2RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Crem
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2402
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.