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Gene: Crem (cAMP responsive element modulator) Rattus norvegicus
Symbol: Crem
Name: cAMP responsive element modulator
CRRD ID: 2402
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including glucose metabolic process; regulation of circadian rhythm; and retinoic acid receptor signaling pathway. Predicted to localize to cytoplasm; nucleus; and transcription regulator complex. Biomarker of transient cerebral ischemia. Orthologous to human CREM (cAMP responsive element modulator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP responsive element moderator; cAMP-responsive element modulator; CRE modulator; CREM delta C-G; CREM-17X; Icer; inducible cyclic AMP early repressor
Homo sapiens (human) : CREM (cAMP responsive element modulator)  HGNC  Alliance
Mus musculus (house mouse) : Crem (cAMP responsive element modulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crem (cAMP responsive element modulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CREM (cAMP responsive element modulator)
Canis lupus familiaris (dog) : CREM (cAMP responsive element modulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crem (cAMP responsive element modulator)
Sus scrofa (pig) : CREM (cAMP responsive element modulator)
Chlorocebus sabaeus (African green monkey) : CREM (cAMP responsive element modulator)
Heterocephalus glaber (naked mole-rat) : Crem (cAMP responsive element modulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01757,021,704 - 57,090,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1757,031,766 - 57,090,888 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01755,055,678 - 55,122,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41762,770,633 - 62,837,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11762,793,252 - 62,846,993 (+)NCBI
Celera1750,219,777 - 50,286,184 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
RH 3.4 Map17555.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Crem
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2402
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.