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Gene: Crk (CRK proto-oncogene, adaptor protein) Rattus norvegicus
Symbol: Crk
Name: CRK proto-oncogene, adaptor protein
Description: Exhibits several functions, including insulin-like growth factor receptor binding activity; protein tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to nitric oxide; and response to peptide hormone. Localizes to membrane raft. Biomarker of degenerative disc disease. Orthologous to human CRK (CRK proto-oncogene, adaptor protein); PARTICIPATES IN E-cadherin signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CrkII; Crko; p38; proto-oncogene C-crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian)
Homo sapiens (human) : CRK (CRK proto-oncogene, adaptor protein)  HGNC  Alliance
Mus musculus (house mouse) : Crk (v-crk avian sarcoma virus CT10 oncogene homolog)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crk (CRK proto-oncogene, adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CRK (CRK proto-oncogene, adaptor protein)
Canis lupus familiaris (dog) : CRK (CRK proto-oncogene, adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crk (CRK proto-oncogene, adaptor protein)
Sus scrofa (pig) : CRK (CRK proto-oncogene, adaptor protein)
Chlorocebus sabaeus (African green monkey) : CRK (CRK proto-oncogene, adaptor protein)
Heterocephalus glaber (naked mole-rat) : Crk (CRK proto-oncogene, adaptor protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01063,829,731 - 63,855,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,829,807 - 63,852,780 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,149,243 - 64,175,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41063,017,662 - 63,040,420 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11063,031,284 - 63,054,043 (+)NCBI
Celera1059,556,811 - 59,579,568 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Crk
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2405
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.