Gene: Crk (CRK proto-oncogene, adaptor protein) Rattus norvegicus
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Symbol: Crk
Name: CRK proto-oncogene, adaptor protein
Description: Exhibits several functions, including cytoskeletal protein binding activity, insulin-like growth factor receptor binding activity, and protein binding activity, bridging; involved in several processes, including cellular response to growth factor stimulus, cellular response to nitric oxide, and response to peptide; localizes to the membrane raft; biomarker of degenerative disc disease; orthologous to human CRK (CRK proto-oncogene, adaptor protein); PARTICIPATES IN E-cadherin signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CrkII; Crko; p38; proto-oncogene C-crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian)
Orthologs:
Homo sapiens (human) : CRK (CRK proto-oncogene, adaptor protein)  HGNC  Alliance
Mus musculus (house mouse) : Crk (v-crk avian sarcoma virus CT10 oncogene homolog)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crk (CRK proto-oncogene, adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CRK (CRK proto-oncogene, adaptor protein)
Canis lupus familiaris (dog) : CRK (CRK proto-oncogene, adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crk (CRK proto-oncogene, adaptor protein)
Sus scrofa (pig) : CRK (CRK proto-oncogene, adaptor protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01063,829,731 - 63,855,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01064,149,243 - 64,175,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41063,017,662 - 63,040,420 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11063,031,284 - 63,054,043 (+)NCBI
Celera1059,556,811 - 59,579,568 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Crk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2405
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.