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Gene: Cryaa (crystallin, alpha A) Rattus norvegicus
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Symbol: Cryaa
Name: crystallin, alpha A
Description: Exhibits identical protein binding activity. Involved in several processes, including protein folding; protein homooligomerization; and response to lead ion. Localizes to the cytoplasm. Used to study cataract. Biomarker of cataract; galactosemia; and ocular hypertension. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to several human genes including CRYAA2 (crystallin alpha A2); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-alpha-tocopherol; (R)-lipoic acid; 5-azacytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Acry-1; alpha-crystallin A chain; Crya1; Crystallin alpha polypeptide A; Crystallin, alpha polypeptide A
Orthologs:
Homo sapiens (human) : CRYAA (crystallin alpha A)  HGNC  Alliance
Mus musculus (house mouse) : Cryaa (crystallin, alpha A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cryaa (crystallin alpha A)
Canis lupus familiaris (dog) : CRYAA (crystallin alpha A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cryaa (crystallin alpha A)
Sus scrofa (pig) : CRYAA (crystallin alpha A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02010,438,444 - 10,442,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02012,621,549 - 12,625,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2011,297,259 - 11,301,004 (+)NCBICelera
Cytogenetic Map20p12NCBI
RH 3.4 Map20134.02RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cryaa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2413
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.