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Gene: Cryab (crystallin, alpha B) Rattus norvegicus
Symbol: Cryab
Name: crystallin, alpha B
CRRD ID: 2414
Description: Exhibits microtubule binding activity. Involved in several processes, including negative regulation of reactive oxygen species metabolic process; response to estradiol; and stress-activated MAPK cascade. Localizes to several cellular components, including cytoskeleton; myofibril; and perikaryon. Biomarker of cataract and macular degeneration. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AACRYA; alpha B-crystallin; alpha(B)-crystallin; alpha-crystallin B chain; crystallin alpha polypeptide 2; crystallin, alpha polypeptide 2
Homo sapiens (human) : CRYAB (crystallin alpha B)  HGNC  Alliance
Mus musculus (house mouse) : Cryab (crystallin, alpha B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cryab (crystallin alpha B)
Pan paniscus (bonobo/pygmy chimpanzee) : CRYAB (crystallin alpha B)
Canis lupus familiaris (dog) : CRYAB (crystallin alpha B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cryab (crystallin alpha B)
Sus scrofa (pig) : CRYAB (crystallin alpha B)
Chlorocebus sabaeus (African green monkey) : CRYAB (crystallin alpha B)
Heterocephalus glaber (naked mole-rat) : Cryab (crystallin alpha B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0855,178,543 - 55,182,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,776,100 - 53,779,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,107,824 - 54,111,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1854,126,302 - 54,130,559 (+)NCBI
Celera850,642,744 - 50,646,745 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cryab
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2414
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.