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Gene: Cst3 (cystatin C) Rattus norvegicus
Symbol: Cst3
Name: cystatin C
Description: Exhibits peptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ development; circadian sleep/wake cycle, REM sleep; and embryo implantation. Localizes to several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (cystatin C); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CYSC; cystatin 3; Cystatin C (cysteine proteinase inhibitor); cystatin-3; cystatin-C; MGC105556
Homo sapiens (human) : CST3 (cystatin C)  HGNC  Alliance
Mus musculus (house mouse) : Cst3 (cystatin C)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cst3 (cystatin C)
Pan paniscus (bonobo/pygmy chimpanzee) : CST3 (cystatin C)
Canis lupus familiaris (dog) : LOC607874 (cystatin-C-like)
Sus scrofa (pig) : CST3 (cystatin C)
Chlorocebus sabaeus (African green monkey) : CST3 (cystatin C)
more info ...
Allele / Splice: Cst3Tn(sb-T2/Bart3)2.172Mcwi   Cst3em1Mcwi   Cst3em3Mcwi  
Genetic Models: F344-Cst3Tn(sb-T2/Bart3)2.172Mcwi SS-Cst3em1Mcwi SS-Cst3em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03143,219,671 - 143,223,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,219,686 - 143,223,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,628,692 - 149,632,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,650,903 - 137,654,776 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13137,556,481 - 137,560,243 (-)NCBI
Celera3135,178,032 - 135,181,905 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cst3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2432
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.