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Gene: Cth (cystathionine gamma-lyase) Rattus norvegicus
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Symbol: Cth
Name: cystathionine gamma-lyase
Description: Exhibits cystathionine beta-lyase activity. Involved in several processes, including glutathione metabolic process; negative regulation of cell growth; and sulfur amino acid metabolic process. Predicted to localize to the cytoplasm. Used to study cataract. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase); PARTICIPATES IN cysteine metabolic pathway; transsulfuration pathway of homocysteine metabolism; cystathioninuria pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CTL target antigen; cystathionase (cystathionine gamma-lyase); cysteine-protein sulfhydrase; gamma-cystathionase; H; PRB-RA; probasin-related antigen
Orthologs:
Homo sapiens (human) : CTH (cystathionine gamma-lyase)  HGNC  Alliance
Mus musculus (house mouse) : Cth (cystathionase (cystathionine gamma-lyase))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cth (cystathionine gamma-lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : CTH (cystathionine gamma-lyase)
Canis lupus familiaris (dog) : CTH (cystathionine gamma-lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cth (cystathionine gamma-lyase)
Sus scrofa (pig) : CTH (cystathionine gamma-lyase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02264,266,959 - 264,293,040 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)Ensembl
Rnor_5.02282,366,125 - 282,392,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42256,056,562 - 256,082,248 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12256,071,168 - 256,096,855 (-)NCBI
Celera2238,776,532 - 238,802,647 (-)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cth
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2443
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.