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Gene: Ctsl (cathepsin L) Rattus norvegicus
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Symbol: Ctsl
Name: cathepsin L
Description: Exhibits kininogen binding activity; peptidase activity, acting on L-amino acid peptides; and peptide binding activity. Involved in several processes, including autophagic cell death; reproductive structure development; and response to odorant. Localizes to several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (cathepsin V); PARTICIPATES IN chaperone mediated autophagy pathway; antigen processing and presentation pathway; phagocytosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cathepsin L1; CATHL; CatL; CP-2; Ctsl1; cyclic protein 2; major excreted protein; MEP
Orthologs:
Homo sapiens (human) : CTSL (cathepsin L)  HGNC  Alliance
Mus musculus (house mouse) : Ctsl (cathepsin L)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CTSL (cathepsin L)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctsl (cathepsin L)
Sus scrofa (pig) : CTSL (cathepsin L)
Chlorocebus sabaeus (African green monkey) : CTSL (cathepsin L)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0171,873,105 - 1,879,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,861,403 - 1,867,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,288,013 - 6,294,174 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1176,288,015 - 6,294,173 (+)NCBI
Celera171,745,833 - 1,751,993 (-)NCBICelera
Cytogenetic Map17p14NCBI
RH 3.4 Map1716.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ctsl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2448
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.