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Gene: Cyp11b2 (cytochrome P450, family 11, subfamily b, polypeptide 2) Rattus norvegicus
Symbol: Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
CRRD ID: 2454
Description: Exhibits corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to nutrient levels; response to peptide hormone; and steroid biosynthetic process. Localizes to dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (cytochrome P450 family 11 subfamily B member 1); PARTICIPATES IN C21-steroid hormone biosynthetic pathway; 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ALDOS; aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; Cp45as; Cyp11b3; CYPXIB2; CYPXIB3; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome P450, subfamily 11B, polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; P450-Aldo-1; P450-Aldo-2; RNCP45AS; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B2; steroid 18-hydroxylase
Allele / Splice: Cyp11b2m1  
Is Marker For: Strains:   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07116,248,759 - 116,255,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,151,128 - 116,157,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,043,365 - 113,049,779 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17113,077,595 - 113,084,003 (-)NCBI
Celera7103,210,977 - 103,217,398 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cyp11b2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2454
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.