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Gene: Cyp21a1 (cytochrome P450, family 21, subfamily a, polypeptide 1) Rattus norvegicus
Symbol: Cyp21a1
Name: cytochrome P450, family 21, subfamily a, polypeptide 1
CRRD ID: 2461
Description: Exhibits steroid 21-monooxygenase activity. Involved in cellular hormone metabolic process; cellular response to peptide hormone stimulus; and response to antibiotic. Predicted to localize to endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; atorvastatin calcium.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 21-OH; 21-OHase; Cyp21; cytochrome P-450c21; cytochrome P450 21 steroid 21 hydroxylase; Cytochrome P450 subfamily XXI (steroid 21-hydroxylase); cytochrome P450 XXI; cytochrome P450, subfamily 21A, polypeptide 1; Cytochrome P450, subfamily XXI (steroid 21-hydroxylase); cytochrome P450-C21; P-450c21; P450-C21; steroid 21-hydroxylase
Related Pseudogenes: Cyp21a1-ps  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,486,213 - 4,489,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,486,219 - 4,489,550 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,565,575 - 6,569,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,125,357 - 4,128,518 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,125,583 - 4,128,745 (+)NCBI
Celera204,003,177 - 4,005,586 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cyp21a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2461
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.