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Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) Rattus norvegicus
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Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Description: Exhibits Hsp70 protein binding activity; Hsp90 protein binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including response to ethanol; response to ozone; and triglyceride metabolic process. Localizes to the Golgi membrane; intrinsic component of endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; fatty liver disease (multiple); liver disease (multiple); middle cerebral artery infarction; and obesity. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4-nitrophenol 2-hydroxylase; Cyp2e; CYPIIE1; cytochrome P450 2E1; Cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily 2e1 (ethanol-inducible); cytochrome P450-J; cytochrome P450RLM6; P450-J; P450RLM6
Orthologs:
Homo sapiens (human) : CYP2E1 (cytochrome P450 family 2 subfamily E member 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102026028 (cytochrome P450 2E1)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100981327 (cytochrome P450 2E1)
Canis lupus familiaris (dog) : CYP2E1 (cytochrome P450 family 2 subfamily E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101973029 (cytochrome P450 2E1)
Sus scrofa (pig) : CYP2E1 (cytochrome P450, family 2, subfamily E, polypeptide 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences