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Gene: Cyp51 (cytochrome P450, family 51) Rattus norvegicus
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Symbol: Cyp51
Name: cytochrome P450, family 51
Description: Exhibits sterol 14-demethylase activity. Involved in cholesterol biosynthetic process via 24,25-dihydrolanosterol. Localizes to the intracellular membrane-bounded organelle. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp51a1; CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, subfamily 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; LDM; MGC93630; P450-14DM; P45014DM; P450LI; RATCP14DM; sterol 14-alpha demethylase
Orthologs:
Homo sapiens (human) : CYP51A1 (cytochrome P450 family 51 subfamily A member 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyp51 (cytochrome P450, family 51)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102027002 (lanosterol 14-alpha demethylase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100985833 (lanosterol 14-alpha demethylase)
Canis lupus familiaris (dog) : CYP51A1 (cytochrome P450 family 51 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101955024 (lanosterol 14-alpha demethylase)
Sus scrofa (pig) : CYP51 (cytochrome P450, family 51, subfamily A, polypeptide 1)
more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Celera425,462,810 - 25,481,264 (+)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp51
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2481
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.