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Gene: Cyp7a1 (cytochrome P450 family 7 subfamily A member 1) Rattus norvegicus
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Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
CRRD ID: 2482
Description: Exhibits cholesterol 7-alpha-monooxygenase activity. Involved in several processes, including bile acid biosynthetic process; cellular response to cholesterol; and regulation of lipid biosynthetic process. Localizes to intracellular membrane-bounded organelle. Biomarker of alcoholic hepatitis; cholestasis; extrahepatic cholestasis; and non-alcoholic steatohepatitis. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1); PARTICIPATES IN bile acid signaling pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; CHAP; cholesterol 7 alpha-hydroxylase; cholesterol 7-alpha hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; CYP7; CYP7S1; CYPVII; Cytochrom P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 7A1; cytochrome P450, 7a1; cytochrome P450, family 7, subfamily a, polypeptide 1
Orthologs:
Homo sapiens (human) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102008593 (cholesterol 7-alpha-monooxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Canis lupus familiaris (dog) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101970910 (cholesterol 7-alpha-monooxygenase)
Sus scrofa (pig) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Chlorocebus sabaeus (African green monkey) : CYP7A1 (cytochrome P450 family 7 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101701685 (cholesterol 7-alpha-monooxygenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0519,358,734 - 19,368,431 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl519,358,734 - 19,368,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0524,143,589 - 24,153,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4519,707,159 - 19,716,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1519,707,158 - 19,716,856 (-)NCBI
Celera518,677,267 - 18,686,964 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp7a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2482
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.