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Gene: Cyp7b1 (cytochrome P450 family 7 subfamily B member 1) Rattus norvegicus
Symbol: Cyp7b1
Name: cytochrome P450 family 7 subfamily B member 1
CRRD ID: 2483
Description: Predicted to have oxysterol 7-alpha-hydroxylase activity. Involved in several processes, including memory; response to cAMP; and response to drug. Predicted to localize to endoplasmic reticulum membrane and integral component of membrane. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 25-hydroxycholesterol 7-alpha-hydroxylase; Cytochrom P450; cytochrome P450 7B1; cytochrome P450, family 7, subfamily b, polypeptide 1; cytochrome P450, subfamily 7B, polypeptide 1; HCT-1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase
Allele / Splice: Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi  
Genetic Models: F344-Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: spans an assembly gap
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02102,701,903 - 102,871,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02122,442,002 - 122,610,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42103,102,679 - 103,271,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12103,048,320 - 103,073,714 (-)NCBI
Celera295,908,860 - 96,075,269 (-)NCBICelera
Cytogenetic Map2q24NCBI
RH 3.4 Map2606.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cyp7b1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2483
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.