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Gene: Dcc (DCC netrin 1 receptor) Rattus norvegicus
Symbol: Dcc
Name: DCC netrin 1 receptor
CRRD ID: 2492
Description: Exhibits identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in generation of neurons; positive regulation of ERK1 and ERK2 cascade; and response to amphetamine. Localizes to growth cone membrane and membrane raft. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH 6-propyl-2-thiouracil; androgen antagonist; bis(2-ethylhexyl) phthalate.
Type: protein-coding
Also known as: colorectal tumor suppressor; Deleted in colcorectal cancer (rat homolog); deleted in colorectal carcinoma; netrin receptor DCC; putative colorectal tumor suppressor; tumor suppressor protein DCC
Homo sapiens (human) : DCC (DCC netrin 1 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Dcc (deleted in colorectal carcinoma)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dcc (DCC netrin 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : DCC (DCC netrin 1 receptor)
Canis lupus familiaris (dog) : DCC (DCC netrin 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dcc (DCC netrin 1 receptor)
Sus scrofa (pig) : DCC (DCC netrin 1 receptor)
Chlorocebus sabaeus (African green monkey) : DCC (DCC netrin 1 receptor)
Heterocephalus glaber (naked mole-rat) : Dcc (DCC netrin 1 receptor)
more info ...
Allele / Splice: DccTn(sb-T2/Bart3)2.205Mcwi  
Genetic Models: F344-DccTn(sb-T2/Bart3)2.205Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01866,518,213 - 67,629,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1866,523,120 - 67,224,566 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01865,688,901 - 66,793,126 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41868,026,795 - 69,140,741 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11868,099,995 - 69,213,942 (-)NCBI
Celera1862,907,666 - 64,001,277 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dcc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2492
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.