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Gene: Dhfr (dihydrofolate reductase) Rattus norvegicus
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Symbol: Dhfr
Name: dihydrofolate reductase
Description: Exhibits NADP binding activity; dihydrofolate reductase activity; and dihydrofolic acid binding activity. Involved in several processes, including axon regeneration; folic acid-containing compound metabolic process; and response to methotrexate. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in precursor lymphoblastic lymphoma/leukemia. Orthologous to several human genes including DHFR (dihydrofolate reductase) and DHFR2 (dihydrofolate reductase 2); PARTICIPATES IN folate mediated one-carbon metabolic pathway; folate metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Dhfr1; Dihydrofolate reductase 1 (active)
Orthologs:
Homo sapiens (human) : DHFR (dihydrofolate reductase)  HGNC  Alliance
Mus musculus (house mouse) : Dhfr (dihydrofolate reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhfr (dihydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHFR (dihydrofolate reductase)
Canis lupus familiaris (dog) : DHFR (dihydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhfr (dihydrofolate reductase)
Sus scrofa (pig) : DHFR (dihydrofolate reductase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0221,931,887 - 21,958,927 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0241,162,308 - 41,162,496 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0241,137,784 - 41,149,417 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,607,093 - 22,828,487 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1222,527,461 - 22,748,856 (+)NCBI
Celera219,675,965 - 19,700,103 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dhfr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2500
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.