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Gene: Dio1 (iodothyronine deiodinase 1) Rattus norvegicus
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Symbol: Dio1
Name: iodothyronine deiodinase 1
Description: Exhibits thyroxine 5'-deiodinase activity. Predicted to be involved in thyroid hormone metabolic process. Predicted to localize to the endoplasmic reticulum membrane and integral component of membrane. Orthologous to human DIO1 (iodothyronine deiodinase 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DI; deiodinase iodothyronine type 1; deiodinase, iodothyronine, type 1; deiodinase, iodothyronine, type I; DIOI; ITDI1; MGC93462; Thyroxine deiodinase type I; thyroxine deiodinase, type I; TXDI1; type 1 DI; type I iodothyronine deiodinase; type-I 5'-deiodinase
Orthologs:
Homo sapiens (human) : DIO1 (iodothyronine deiodinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Dio1 (deiodinase, iodothyronine, type I)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio1 (iodothyronine deiodinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO1 (iodothyronine deiodinase 1)
Canis lupus familiaris (dog) : DIO1 (iodothyronine deiodinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio1 (iodothyronine deiodinase 1)
Sus scrofa (pig) : DIO1 (iodothyronine deiodinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05126,894,837 - 126,911,532 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05130,744,425 - 130,760,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45128,385,702 - 128,404,015 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15128,390,932 - 128,409,240 (-)NCBI
Celera5120,820,006 - 120,836,676 (-)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dio1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2504
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.