Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dio1 (iodothyronine deiodinase 1) Rattus norvegicus
Symbol: Dio1
Name: iodothyronine deiodinase 1
Description: Exhibits thyroxine 5'-deiodinase activity. Predicted to be involved in thyroid hormone metabolic process. Predicted to localize to endoplasmic reticulum membrane and integral component of membrane. Orthologous to human DIO1 (iodothyronine deiodinase 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DI; deiodinase iodothyronine type 1; deiodinase, iodothyronine, type 1; deiodinase, iodothyronine, type I; DIOI; ITDI1; MGC93462; Thyroxine deiodinase type I; thyroxine deiodinase, type I; TXDI1; type 1 DI; type I iodothyronine deiodinase; type-I 5'-deiodinase
Homo sapiens (human) : DIO1 (iodothyronine deiodinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Dio1 (deiodinase, iodothyronine, type I)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio1 (iodothyronine deiodinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO1 (iodothyronine deiodinase 1)
Canis lupus familiaris (dog) : DIO1 (iodothyronine deiodinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio1 (iodothyronine deiodinase 1)
Sus scrofa (pig) : DIO1 (iodothyronine deiodinase 1)
Chlorocebus sabaeus (African green monkey) : DIO1 (iodothyronine deiodinase 1)
Heterocephalus glaber (naked mole-rat) : Dio1 (iodothyronine deiodinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05126,894,837 - 126,911,532 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,895,286 - 126,911,520 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05130,744,425 - 130,760,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45128,385,702 - 128,404,015 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15128,390,932 - 128,409,240 (-)NCBI
Celera5120,820,006 - 120,836,676 (-)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dio1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2504
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.