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Gene: Drd2 (dopamine receptor D2) Rattus norvegicus
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Symbol: Drd2
Name: dopamine receptor D2
Description: Exhibits several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including nervous system development; regulation of ion transport; and regulation of protein modification process. Localizes to several cellular components, including cytoplasmic vesicle; integral component of synaptic membrane; and lateral plasma membrane. Used to study cocaine dependence and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); end stage renal failure; mental depression; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; (+)-pilocarpine; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor 2
Orthologs:
Homo sapiens (human) : DRD2 (dopamine receptor D2)  HGNC  Alliance
Mus musculus (house mouse) : Drd2 (dopamine receptor D2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd2 (dopamine receptor D2)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD2 (dopamine receptor D2)
Canis lupus familiaris (dog) : DRD2 (dopamine receptor D2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd2 (dopamine receptor D2)
Sus scrofa (pig) : DRD2 (dopamine receptor D2)
Chlorocebus sabaeus (African green monkey) : DRD2 (dopamine receptor D2)
Heterocephalus glaber (naked mole-rat) : Drd2 (dopamine receptor D2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Drd2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2520
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.