Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Drd4 (dopamine receptor D4) Rattus norvegicus
Symbol: Drd4
Name: dopamine receptor D4
Description: Exhibits dopamine binding activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including behavioral fear response; learning or memory; and modulation of chemical synaptic transmission. Localizes to several cellular components, including GABA-ergic synapse; glutamatergic synapse; and integral component of synaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH 1,2-dimethylhydrazine; 3,7-dihydropurine-6-thione; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: d(2C) dopamine receptor; D(4) dopamine receptor; D4RA; dopamine D4 receptor; dopamine receptor 4
Homo sapiens (human) : DRD4 (dopamine receptor D4)  HGNC  Alliance
Mus musculus (house mouse) : Drd4 (dopamine receptor D4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd4 (dopamine receptor D4)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD4 (dopamine receptor D4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd4 (dopamine receptor D4)
Sus scrofa (pig) : DRD4 (dopamine receptor D4)
Chlorocebus sabaeus (African green monkey) : DRD4 (dopamine receptor D4)
Heterocephalus glaber (naked mole-rat) : Drd4 (dopamine receptor D4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01214,278,296 - 214,282,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,278,296 - 214,281,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,195,844 - 221,200,366 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,485,597 - 201,488,784 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,636,931 - 201,640,119 (+)NCBI
Celera1194,030,237 - 194,033,424 (+)NCBICelera
Cytogenetic Map1q41NCBI
RH 3.4 Map11437.21RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Drd4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2522
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.