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Gene: Hbegf (heparin-binding EGF-like growth factor) Rattus norvegicus
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Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
Description: Exhibits epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; and positive regulation of cell growth. Predicted to localize to the cell surface; extracellular space; and integral component of plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; (RS)-amphetamine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); Dtr; GFHB; Hb-egf; Hegfl; heparin binding epidermal growth factor-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal -growth factor; proheparin-binding EGF-like growth factor
Orthologs:
Homo sapiens (human) : HBEGF (heparin binding EGF like growth factor)  HGNC  Alliance
Mus musculus (house mouse) : Hbegf (heparin-binding EGF-like growth factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hbegf (heparin binding EGF like growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : HBEGF (heparin binding EGF like growth factor)
Canis lupus familiaris (dog) : HBEGF (heparin binding EGF like growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hbegf (heparin binding EGF like growth factor)
Sus scrofa (pig) : HBEGF (heparin binding EGF like growth factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01829,330,302 - 29,340,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01829,036,863 - 29,046,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,143,567 - 29,153,944 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11829,170,212 - 29,180,590 (-)NCBI
Celera1827,834,537 - 27,844,179 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hbegf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2526
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.