Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A) Rattus norvegicus
Symbol: Dyrk1a
Name: dual specificity tyrosine phosphorylation regulated kinase 1A
CRRD ID: 2528
Description: Exhibits protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation and regulation of RNA splicing. Localizes to nuclear speck. Predicted to colocalize with actin filament; microtubule; and neurofilament. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ageladine A.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual Specificity Yak1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dyrk; MNBH; protein kinase minibrain homolog; PSK47; RP86
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01134,858,339 - 34,958,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,453,019 - 38,550,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,879,733 - 34,970,998 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,935,975 - 35,027,241 (+)NCBI
Celera1134,444,072 - 34,535,020 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dyrk1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2528
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.