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Gene: Edn1 (endothelin 1) Rattus norvegicus
Symbol: Edn1
Name: endothelin 1
Description: Exhibits endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to corticosteroid; and response to fatty acid. Localizes to several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1); PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endothelin-1; ET-1; Et1; PPET1; preproendothelin-1
Homo sapiens (human) : EDN1 (endothelin 1)  HGNC  Alliance
Mus musculus (house mouse) : Edn1 (endothelin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn1 (endothelin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN1 (endothelin 1)
Canis lupus familiaris (dog) : EDN1 (endothelin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn1 (endothelin 1)
Sus scrofa (pig) : EDN1 (endothelin 1)
Chlorocebus sabaeus (African green monkey) : EDN1 (endothelin 1)
Heterocephalus glaber (naked mole-rat) : Edn1 (endothelin 1)
more info ...
Is Marker For: Strains:   SD   F344.OLETF-(D17Mgh4-Edn1)/Tj  
QTLs:   Niddm32  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Edn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2532
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.