Gene: Edn1 (endothelin 1) Rattus norvegicus
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Symbol: Edn1
Name: endothelin 1
Description: Exhibits endothelin A receptor binding activity and endothelin B receptor binding activity; involved in several processes, including cellular response to cytokine stimulus, cellular response to hormone stimulus, and regulation of gene expression; localizes to the basal part of cell, cytoplasm, and extracellular space; used to study adult respiratory distress syndrome, coronary artery disease, membranoproliferative glomerulonephritis, metabolic acidosis, and portal hypertension; biomarker of several diseases, including artery disease (multiple), kidney failure (multiple), liver disease (multiple), lung disease (multiple), and nephritis (multiple); orthologous to human EDN1 (endothelin 1); PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endothelin-1; ET-1; Et1; PPET1; preproendothelin-1
Orthologs:
Homo sapiens (human) : EDN1 (endothelin 1)  HGNC  Alliance
Mus musculus (house mouse) : Edn1 (endothelin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn1 (endothelin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN1 (endothelin 1)
Canis lupus familiaris (dog) : EDN1 (endothelin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn1 (endothelin 1)
Sus scrofa (pig) : EDN1 (endothelin 1)
more info ...
Is Marker For: Strains:   SD   F344.OLETF-(D17Mgh4-Edn1)/Tj  
QTLs:   Niddm32  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)