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Gene: Edn2 (endothelin 2) Rattus norvegicus
Symbol: Edn2
Name: endothelin 2
CRRD ID: 2533
Description: Predicted to have endothelin B receptor binding activity and hormone activity. Involved in several processes, including ovarian follicle rupture; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of hormone secretion. Localizes to extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human EDN2 (endothelin 2); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; BQ 123.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Endothelin isopeptide 2; endothelin-2; ET-2; Et2; PPET2; preproendothelin-2; RNEDN2S01; vasoactive intestinal contractor; VIC
Homo sapiens (human) : EDN2 (endothelin 2)  HGNC  Alliance
Mus musculus (house mouse) : Edn2 (endothelin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn2 (endothelin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN2 (endothelin 2)
Canis lupus familiaris (dog) : EDN2 (endothelin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn2 (endothelin 2)
Sus scrofa (pig) : EDN2 (endothelin 2)
Chlorocebus sabaeus (African green monkey) : EDN2 (endothelin 2)
Heterocephalus glaber (naked mole-rat) : Edn2 (endothelin 2)
more info ...
Is Marker For: QTLs:   Bp7  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05139,098,472 - 139,106,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,100,898 - 139,105,792 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,891,221 - 142,896,115 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45140,742,686 - 140,747,580 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15140,747,827 - 140,753,399 (+)NCBI
Celera5132,309,615 - 132,315,113 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Edn2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2533
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.