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Gene: Ednrb (endothelin receptor type B) Rattus norvegicus
Symbol: Ednrb
Name: endothelin receptor type B
Description: Exhibits endothelin receptor activity and type 1 angiotensin receptor binding activity. Involved in several processes, including enteric nervous system development; positive regulation of penile erection; and regulation of blood vessel diameter. Localizes to membrane raft; nuclear membrane; and plasma membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and sensorineural hearing loss. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome type 4A; Waardenburg's syndrome; and asthma. Orthologous to human EDNRB (endothelin receptor type B); PARTICIPATES IN calcium/calmodulin dependent kinase signaling pathway; endothelin signaling pathway; inflammatory response pathway; INTERACTS WITH (R)-noradrenaline; (S)-colchicine; (S)-nicotine.
Type: protein-coding
Also known as: Ednra; endothelin B receptor; endothelin receptor; endothelin receptor non-selective type; endothelin-B receptor; ET-B; ET-BR; Etb
Homo sapiens (human) : EDNRB (endothelin receptor type B)  HGNC  Alliance
Mus musculus (house mouse) : Ednrb (endothelin receptor type B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ednrb (endothelin receptor type B)
Pan paniscus (bonobo/pygmy chimpanzee) : EDNRB (endothelin receptor type B)
Canis lupus familiaris (dog) : EDNRB (endothelin receptor type B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ednrb (endothelin receptor type B)
Sus scrofa (pig) : EDNRB (endothelin receptor type B)
Chlorocebus sabaeus (African green monkey) : EDNRB (endothelin receptor type B)
Heterocephalus glaber (naked mole-rat) : Ednrb (endothelin receptor type B)
more info ...
Allele / Splice: Ednrbsl  
Genetic Models: Sl LE/Hkv.AR-Ednrbsl F344.AR-Ednrbsl/Hkv AR-Ednrbsl/Hkv LE.AR-Ednrbsl/Okkm AR-Ednrbsl/Okkm
Is Marker For: Strains:   DA   SI-Tg(Ednrb)Ywa   Sl   LE.AR-Ednrbsl/Okkm   AR-Ednrbsl/Okkm   AR-Ednrbsl/Hkv   LE/Hkv.AR-Ednrbsl   F344.AR-Ednrbsl/Hkv  
QTLs:   Scl1   BpQTLcluster12   Bp126   Gluco31  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01588,004,775 - 88,036,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01591,500,400 - 91,531,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,893,141 - 87,898,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11587,908,924 - 87,914,471 (-)NCBI
Celera1579,772,740 - 79,801,760 (-)NCBICelera
Cytogenetic Map15q22NCBI
RH 3.4 Map15496.21RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ednrb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2536
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.