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Gene: Egr1 (early growth response 1) Rattus norvegicus
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Symbol: Egr1
Name: early growth response 1
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to organonitrogen compound; and regulation of synaptic plasticity. Localizes to cytoplasm and nucleus. Used to study myeloid neoplasm. Biomarker of several diseases, including liver cirrhosis; lung disease (multiple); middle cerebral artery infarction; pulmonary hypertension; and visual epilepsy. Human ortholog(s) of this gene implicated in asthma and myeloid neoplasm. Orthologous to human EGR1 (early growth response 1); PARTICIPATES IN long term potentiation; prion disease pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: early growth response protein 1; EGR-1; Krox-24; Nerve growth factor-induced gene; nerve growth factor-induced protein A; Ngf1; Ngfi; NGFI-A; transcription factor Zif268; zif-268; zinc finger protein Krox-24
Orthologs:
Homo sapiens (human) : EGR1 (early growth response 1)  HGNC  Alliance
Mus musculus (house mouse) : Egr1 (early growth response 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egr1 (early growth response 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EGR1 (early growth response 1)
Canis lupus familiaris (dog) : EGR1 (early growth response 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egr1 (early growth response 1)
Sus scrofa (pig) : EGR1 (early growth response 1)
Chlorocebus sabaeus (African green monkey) : EGR1 (early growth response 1)
Heterocephalus glaber (naked mole-rat) : Egr1 (early growth response 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
Cytogenetic Map18p12NCBI
RH 3.4 Map18367.2RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Egr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2544
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.