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Gene: Eno2 (enolase 2) Rattus norvegicus
Symbol: Eno2
Name: enolase 2
CRRD ID: 2554
Description: Exhibits enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Involved in several processes, including glucose metabolic process; negative regulation of neuron death; and response to estradiol. Localizes to several cellular components, including growth cone; membrane raft; and phosphopyruvate hydratase complex. Biomarker of toxic shock syndrome and visual epilepsy. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2); PARTICIPATES IN gluconeogenesis pathway; glycolysis pathway; glycolysis/gluconeogenesis pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-phospho-D-glycerate hydro-lyase; Enolase 2 gamma neuronal; enolase 2, gamma; enolase 2, gamma, neuronal; gamma-enolase; neural enolase; neuron-specific enolase; NSE; RNEN3
Homo sapiens (human) : ENO2 (enolase 2)  HGNC  Alliance
Mus musculus (house mouse) : Eno2 (enolase 2, gamma neuronal)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eno2 (enolase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ENO2 (enolase 2)
Canis lupus familiaris (dog) : ENO2 (enolase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eno2 (enolase 2)
Sus scrofa (pig) : ENO2 (enolase 2)
Chlorocebus sabaeus (African green monkey) : ENO2 (enolase 2)
Heterocephalus glaber (naked mole-rat) : Eno2 (enolase 2)
more info ...
Is Marker For: QTLs:   Coreg2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04157,285,192 - 157,294,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,285,179 - 157,294,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,302,788 - 224,311,673 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,891,003 - 160,897,723 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,135,093 - 161,144,004 (-)NCBI
Celera4146,310,173 - 146,318,990 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Eno2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2554
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.