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Gene: Ephx1 (epoxide hydrolase 1) Rattus norvegicus
Symbol: Ephx1
Name: epoxide hydrolase 1
Description: Exhibits cis-stilbene-oxide hydrolase activity; enzyme binding activity; and epoxide hydrolase activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Localizes to the intracellular membrane-bounded organelle and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1); PARTICIPATES IN carbamazepine pharmacokinetics pathway; phenytoin pharmacodynamics pathway; bile acid transport pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: epoxide hydratase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase); epoxide hydrolase 1, microsomal; epoxide hydrolase 1, microsomal (xenobiotic); liver microsomal xenobiotic epoxide hydrolase; mEH; MEH8; microsomal epoxide hydrolase
Homo sapiens (human) : EPHX1 (epoxide hydrolase 1)  HGNC  Alliance
Mus musculus (house mouse) : Ephx1 (epoxide hydrolase 1, microsomal)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephx1 (epoxide hydrolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHX1 (epoxide hydrolase 1)
Canis lupus familiaris (dog) : EPHX1 (epoxide hydrolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephx1 (epoxide hydrolase 1)
Sus scrofa (pig) : EPHX1 (epoxide hydrolase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01399,271,390 - 99,300,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013104,268,704 - 104,297,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,722,973 - 96,752,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,912,126 - 96,925,415 (-)NCBI
Celera1392,256,740 - 92,285,424 (-)NCBICelera
Cytogenetic Map13q26NCBI
RH 3.4 Map13631.9RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ephx1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2557
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.