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Gene: Erbb2 (erb-b2 receptor tyrosine kinase 2) Rattus norvegicus
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Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Description: Exhibits several functions, including Hsp90 protein binding activity; protein heterodimerization activity; and ubiquitin protein ligase binding activity. Predicted to contribute to growth factor binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Localizes to several cellular components, including the apical plasma membrane; basal plasma membrane; and lateral loop. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; malignant glioma; mammary Paget's disease; prostate cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; Ras mediated signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); C-erbB-2; epidermal growth factor receptor-related protein; NEU proto-oncogene; p185erbB2; p185neu; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Orthologs:
Homo sapiens (human) : ERBB2 (erb-b2 receptor tyrosine kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Erbb2 (erb-b2 receptor tyrosine kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb2 (erb-b2 receptor tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Canis lupus familiaris (dog) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb2 (erb-b2 receptor tyrosine kinase 2)
Sus scrofa (pig) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01086,367,596 - 86,391,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01086,163,531 - 86,187,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,219,157 - 87,242,919 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,233,617 - 87,256,603 (+)NCBI
Celera1082,158,844 - 82,182,518 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Erbb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2561
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.