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Gene: Esr2 (estrogen receptor 2) Rattus norvegicus
Symbol: Esr2
Name: estrogen receptor 2
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen response element binding activity; and steroid binding activity. Involved in several processes, including animal organ development; regulation of neuron death; and response to steroid hormone. Localizes to several cellular components, including mitochondrion; perikaryon; and perinuclear region of cytoplasm. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); autoimmune hypersensitivity disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2); PARTICIPATES IN estrogen signaling pathway; bisphenol A response pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (+)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
Also known as: ER-beta; Erb2; ERbeta; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2
Homo sapiens (human) : ESR2 (estrogen receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Esr2 (estrogen receptor 2 (beta))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Esr2 (estrogen receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ESR2 (estrogen receptor 2)
Canis lupus familiaris (dog) : ESR2 (estrogen receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Esr2 (estrogen receptor 2)
Sus scrofa (pig) : ESR2 (estrogen receptor 2)
Chlorocebus sabaeus (African green monkey) : ESR2 (estrogen receptor 2)
Heterocephalus glaber (naked mole-rat) : Esr2 (estrogen receptor 2)
more info ...
Is Marker For: Strains:   SD-Esr2em1Soar  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
Cytogenetic Map6q24NCBI
RH 3.4 Map6686.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)