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Gene: Ms4a2 (membrane spanning 4-domains A2) Rattus norvegicus
Symbol: Ms4a2
Name: membrane spanning 4-domains A2
Description: Exhibits SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to IgE receptor activity. Involved in several processes, including activation of phospholipase C activity; positive regulation of mast cell degranulation; and protein kinase C-activating G protein-coupled receptor signaling pathway. Localizes to endosome; integral component of plasma membrane; and membrane raft. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; and rhinitis. Orthologous to human MS4A2 (membrane spanning 4-domains A2); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; asthma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta polypeptide); fc epsilon receptor I beta-chain; Fcer1b; fcERI; FCIGA; high affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains subfamily A member 2; Membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for, beta polypeptide); Ms4a1
Homo sapiens (human) : MS4A2 (membrane spanning 4-domains A2)  HGNC  Alliance
Mus musculus (house mouse) : Ms4a2 (membrane-spanning 4-domains, subfamily A, member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ms4a2 (membrane spanning 4-domains A2)
Pan paniscus (bonobo/pygmy chimpanzee) : MS4A2 (membrane spanning 4-domains A2)
Canis lupus familiaris (dog) : MS4A2 (membrane spanning 4-domains A2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ms4a2 (membrane spanning 4-domains A2)
Sus scrofa (pig) : MS4A2 (membrane spanning 4-domains A2)
Chlorocebus sabaeus (African green monkey) : MS4A2 (membrane spanning 4-domains A2)
Heterocephalus glaber (naked mole-rat) : Ms4a2 (membrane spanning 4-domains A2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01227,957,363 - 227,965,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1227,957,302 - 227,965,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01235,019,784 - 235,027,733 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,011,050 - 214,018,999 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11214,169,479 - 214,177,429 (+)NCBI
Celera1205,916,298 - 205,924,247 (-)NCBICelera
Cytogenetic Map1q43NCBI
RH 3.4 Map11501.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ms4a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2598
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.