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Gene: Fgf1 (fibroblast growth factor 1) Rattus norvegicus
Symbol: Fgf1
Name: fibroblast growth factor 1
Description: Exhibits Hsp70 protein binding activity and growth factor activity. Involved in cell population proliferation and positive regulation of hepatocyte proliferation. Localizes to cytoplasm and nucleolus. Used to study brain ischemia. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1); PARTICIPATES IN fibroblast growth factor signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: acidic fibroblast growth factor; aFGF; FGF-1; fibroblast growth factor 1 (acidic); Fibroblast growth factor 1 (heparin binding); HBGF-1; HBGF1; heparin-binding growth factor 1
Homo sapiens (human) : FGF1 (fibroblast growth factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Fgf1 (fibroblast growth factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgf1 (fibroblast growth factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FGF1 (fibroblast growth factor 1)
Canis lupus familiaris (dog) : FGF1 (fibroblast growth factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgf1 (fibroblast growth factor 1)
Sus scrofa (pig) : FGF1 (fibroblast growth factor 1)
Chlorocebus sabaeus (African green monkey) : FGF1 (fibroblast growth factor 1)
Heterocephalus glaber (naked mole-rat) : Fgf1 (fibroblast growth factor 1)
more info ...
Allele / Splice: Fgf1em2Mcwi  
Genetic Models: SS-Fgf1em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01832,273,830 - 32,359,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1832,273,770 - 32,359,824 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01831,951,411 - 32,037,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41831,785,480 - 31,806,452 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11831,815,644 - 31,836,615 (-)NCBI
Celera1830,325,334 - 30,346,306 (-)NCBICelera
Cytogenetic Map18p11NCBI
RH 3.4 Map18442.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Fgf1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2605
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.