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Gene: G6pc1 (glucose-6-phosphatase catalytic subunit 1) Rattus norvegicus
Symbol: G6pc1
Name: glucose-6-phosphatase catalytic subunit 1
CRRD ID: 2644
Description: Exhibits glucose-6-phosphatase activity. Involved in several processes, including gluconeogenesis; phosphorylated carbohydrate dephosphorylation; and response to resveratrol. Localizes to intracellular membrane-bounded organelle. Used to study type 2 diabetes mellitus. Biomarker of fatty liver disease. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human G6PC (glucose-6-phosphatase catalytic subunit); PARTICIPATES IN altered galactose metabolic pathway; gluconeogenesis pathway; glycogen degradation pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G-6-Pase; G6PASE; G6pc; Glucose-6-phosphatase; glucose-6-phosphatase, catalytic; glucose-6-phosphatase, catalytic subunit; MGC93613
Homo sapiens (human) : G6PC1 (glucose-6-phosphatase catalytic subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : G6pc (glucose-6-phosphatase, catalytic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : G6pc1 (glucose-6-phosphatase catalytic subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : G6PC1 (glucose-6-phosphatase catalytic subunit 1)
Canis lupus familiaris (dog) : G6PC1 (glucose-6-phosphatase catalytic subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : G6pc1 (glucose-6-phosphatase catalytic subunit 1)
Sus scrofa (pig) : G6PC1 (glucose-6-phosphatase catalytic subunit 1)
Chlorocebus sabaeus (African green monkey) : G6PC1 (glucose-6-phosphatase catalytic subunit 1)
Heterocephalus glaber (naked mole-rat) : G6pc1 (glucose-6-phosphatase catalytic subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01089,286,009 - 89,296,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,084,064 - 89,094,265 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,393,531 - 90,403,485 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11090,407,938 - 90,417,855 (+)NCBI
Celera1085,025,492 - 85,036,580 (+)NCBICelera
Cytogenetic Map10q31NCBI
RH 3.4 Map10837.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on G6pc1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2644
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.