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Gene: Gadd45a (growth arrest and DNA-damage-inducible, alpha) Rattus norvegicus
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
CRRD ID: 2654
Description: Predicted to have several functions, including promoter-specific chromatin binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in G2/M transition of mitotic cell cycle. Predicted to localize to cytoplasm and nuclear speck. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha); PARTICIPATES IN p38 MAPK signaling pathway; cell cycle pathway, mitotic; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; (S)-colchicine.
Type: protein-coding
Also known as: DDIT-1; Ddit1; DNA damage-inducible transcript 1 protein; DNA-damage-inducible transcript 1; Gadd45; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; Growth arrest and DNA-damage-inducible protein; growth arrest and DNA-damage-inducible protein GADD45 alpha
Homo sapiens (human) : GADD45A (growth arrest and DNA damage inducible alpha)  HGNC  Alliance
Mus musculus (house mouse) : Gadd45a (growth arrest and DNA-damage-inducible 45 alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gadd45a (growth arrest and DNA damage inducible alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : GADD45A (growth arrest and DNA damage inducible alpha)
Canis lupus familiaris (dog) : GADD45A (growth arrest and DNA damage inducible alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gadd45a (growth arrest and DNA damage inducible alpha)
Sus scrofa (pig) : GADD45A (growth arrest and DNA damage inducible alpha)
Chlorocebus sabaeus (African green monkey) : GADD45A (growth arrest and DNA damage inducible alpha)
Heterocephalus glaber (naked mole-rat) : Gadd45a (growth arrest and DNA damage inducible alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Celera490,851,517 - 90,853,819 (-)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gadd45a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2654
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.