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Gene: Gck (glucokinase) Rattus norvegicus
Symbol: Gck
Name: glucokinase
CRRD ID: 2670
Description: Exhibits several functions, including adenyl ribonucleotide binding activity; glucose binding activity; and hexokinase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to hormone stimulus; and hexose metabolic process. Localizes to several cellular components, including basal cortex; nucleoplasm; and secretory granule. Colocalizes with actin filament. Used to study fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase); PARTICIPATES IN glycogen biosynthetic pathway; glycogen metabolic pathway; glycolysis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GLK; glucokinase variant 3; GLUKA; hexokinase type IV; hexokinase-4; hexokinase-D; HK IV; HK4; RNGK2
Homo sapiens (human) : GCK (glucokinase)  HGNC  Alliance
Mus musculus (house mouse) : Gck (glucokinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gck (glucokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : GCK (glucokinase)
Canis lupus familiaris (dog) : GCK (glucokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gck (glucokinase)
Sus scrofa (pig) : GCK (glucokinase)
Chlorocebus sabaeus (African green monkey) : GCK (glucokinase)
Heterocephalus glaber (naked mole-rat) : Gck (glucokinase)
more info ...
Is Marker For: QTLs:   Pancm5   Niddm37  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01486,149,146 - 86,191,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,148,928 - 86,190,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,832,735 - 86,875,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,572,518 - 86,587,723 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11486,591,662 - 86,606,868 (-)NCBI
Celera1479,669,432 - 79,710,739 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gck
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2670
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.