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Gene: Gja1 (gap junction protein, alpha 1) Rattus norvegicus
Symbol: Gja1
Name: gap junction protein, alpha 1
Description: Exhibits connexin binding activity; gap junction channel activity; and protein domain specific binding activity. Involved in several processes, including negative regulation of cell population proliferation; regulation of blood vessel diameter; and reproductive structure development. Localizes to several cellular components, including connexin complex; endosome; and fascia adherens. Predicted to colocalize with cell-cell junction. Used to study amnestic disorder; malignant glioma; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; borna disease; ischemia (multiple); and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); erythrokeratodermia variabilis (multiple); oculodentodigital dysplasia; palmoplantar keratoderma and congenital alopecia 1; and syndactyly type 3. Orthologous to human GJA1 (gap junction protein alpha 1); PARTICIPATES IN connexin signaling pathway; N-cadherin signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (-)-antofine; (R)-lipoic acid.
Type: protein-coding
Also known as: connexin 43; connexin k1; connexin-43; Cx43; Cxnk1; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein alpha 1 43 kD; Gap junction protein alpha 1 43 kD (connexin 43); Gap junction protein, alpha 1, 43 kD (connexin 43); MGC93610
Homo sapiens (human) : GJA1 (gap junction protein alpha 1)  HGNC  Alliance
Mus musculus (house mouse) : Gja1 (gap junction protein, alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gja1 (gap junction protein alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GJA1 (gap junction protein alpha 1)
Canis lupus familiaris (dog) : GJA1 (gap junction protein alpha 1)
Sus scrofa (pig) : GJA1 (gap junction protein alpha 1)
Chlorocebus sabaeus (African green monkey) : GJA1 (gap junction protein alpha 1)
Heterocephalus glaber (naked mole-rat) : Gja1 (gap junction protein alpha 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Celera2037,095,121 - 37,107,568 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gja1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2690
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.