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Gene: Gja5 (gap junction protein, alpha 5) Rattus norvegicus
Symbol: Gja5
Name: gap junction protein, alpha 5
CRRD ID: 2692
Description: Exhibits connexin binding activity; disordered domain specific binding activity; and gap junction channel activity. Involved in several processes, including cell communication by chemical coupling; regulation of blood pressure; and regulation of blood vessel diameter. Localizes to cell projection and connexin complex. Used to study hypertension. Biomarker of artery disease (multiple); glomerulonephritis; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (gap junction protein alpha 5); PARTICIPATES IN connexin signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
Also known as: connexin 40; connexin i; connexin-40; Cx40; Cxni; gap junction alpha-5 protein; gap junction membrane channel protein alpha 5; gap junction membrane channel protein alpha 5 (connexin 40)
Homo sapiens (human) : GJA5 (gap junction protein alpha 5)  HGNC  Alliance
Mus musculus (house mouse) : Gja5 (gap junction protein, alpha 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gja5 (gap junction protein alpha 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GJA5 (gap junction protein alpha 5)
Canis lupus familiaris (dog) : GJA5 (gap junction protein alpha 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gja5 (gap junction protein alpha 5)
Sus scrofa (pig) : GJA5 (gap junction protein alpha 5)
Chlorocebus sabaeus (African green monkey) : GJA5 (gap junction protein alpha 5)
Heterocephalus glaber (naked mole-rat) : Gja5 (gap junction protein alpha 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gja5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2692
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.