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Gene: Gls (glutaminase) Rattus norvegicus
Symbol: Gls
Name: glutaminase
Description: Predicted to have glutaminase activity and identical protein binding activity. Predicted to be involved in several processes, including glutamate homeostasis; glutamine family amino acid metabolic process; and protein homotetramerization. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Orthologous to human GLS (glutaminase); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; arginine and proline metabolic pathway; D-glutamine and D-glutamate metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Glut; glutaminase kidney isoform, mitochondrial; K-glutaminase; kidney-type glutaminase; L-glutamine amidohydrolase; RATGLUT
Homo sapiens (human) : GLS (glutaminase)  HGNC  Alliance
Mus musculus (house mouse) : Gls (glutaminase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gls (glutaminase)
Pan paniscus (bonobo/pygmy chimpanzee) : GLS (glutaminase)
Canis lupus familiaris (dog) : GLS (glutaminase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gls (glutaminase)
Sus scrofa (pig) : GLS (glutaminase)
Chlorocebus sabaeus (African green monkey) : GLS (glutaminase)
Heterocephalus glaber (naked mole-rat) : Gls (glutaminase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0954,212,622 - 54,284,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,923,145 - 53,995,543 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,380,165 - 46,452,974 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1946,381,578 - 46,454,381 (+)NCBI
Celera947,008,653 - 47,080,221 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gls
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2707
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.