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Gene: Gnai1 (G protein subunit alpha i1) Rattus norvegicus
Symbol: Gnai1
Name: G protein subunit alpha i1
CRRD ID: 2713
Description: Exhibits several functions, including GTPase activating protein binding activity; magnesium ion binding activity; and purine ribonucleoside binding activity. Involved in several processes, including cellular response to forskolin; negative regulation of synaptic transmission; and regulation of cAMP-mediated signaling. Localizes to several cellular components, including centrosome; membrane raft; and plasma membrane. Orthologous to human GNAI1 (G protein subunit alpha i1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2-methoxyethanol.
Type: protein-coding
Also known as: adenylate cyclase-inhibiting G alpha protein; BPGTPB; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide-binding protein G(i) subunit alpha-1; guanine nucleotide-binding protein G(i), alpha-1 subunit
Homo sapiens (human) : GNAI1 (G protein subunit alpha i1)  HGNC  Alliance
Mus musculus (house mouse) : Gnai1 (guanine nucleotide binding protein (G protein), alpha inhibiting 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnai1 (G protein subunit alpha i1)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAI1 (G protein subunit alpha i1)
Canis lupus familiaris (dog) : GNAI1 (G protein subunit alpha i1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnai1 (G protein subunit alpha i1)
Sus scrofa (pig) : GNAI1 (G protein subunit alpha i1)
Chlorocebus sabaeus (African green monkey) : GNAI1 (G protein subunit alpha i1)
Heterocephalus glaber (naked mole-rat) : Gnai1 (G protein subunit alpha i1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0413,405,136 - 13,486,866 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl413,405,136 - 13,485,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0413,388,073 - 13,470,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4412,465,089 - 12,495,028 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1412,465,088 - 12,495,028 (+)NCBI
Celera412,346,868 - 12,428,695 (+)NCBICelera
Cytogenetic Map4q11NCBI
RH 3.4 Map449.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gnai1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2713
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.