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Gene: Gnai3 (G protein subunit alpha i3) Rattus norvegicus
Symbol: Gnai3
Name: G protein subunit alpha i3
Description: Exhibits G protein-coupled serotonin receptor binding activity; GTPase activating protein binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of NAD(P)H oxidase activity; positive regulation of superoxide anion generation; and positive regulation of vascular smooth muscle cell proliferation. Localizes to membrane raft; plasma membrane; and zymogen granule. Predicted to colocalize with Golgi membrane and endoplasmic reticulum membrane. Biomarker of hypertension. Orthologous to human GNAI3 (G protein subunit alpha i3); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; endothelin signaling pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
Also known as: g(i) alpha-3; GIP3A; guanine nucleotide binding protein (G protein), alpha inhibiting 3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide binding protein alpha inhibiting polypeptide 3; guanine nucleotide binding protein, alpha inhibiting 3; Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3; guanine nucleotide-binding protein G(i) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha
Homo sapiens (human) : GNAI3 (G protein subunit alpha i3)  HGNC  Alliance
Mus musculus (house mouse) : Gnai3 (guanine nucleotide binding protein (G protein), alpha inhibiting 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnai3 (G protein subunit alpha i3)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAI3 (G protein subunit alpha i3)
Canis lupus familiaris (dog) : GNAI3 (G protein subunit alpha i3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnai3 (G protein subunit alpha i3)
Sus scrofa (pig) : GNAI3 (G protein subunit alpha i3)
Chlorocebus sabaeus (African green monkey) : GNAI3 (G protein subunit alpha i3)
Heterocephalus glaber (naked mole-rat) : Gnai3 (G protein subunit alpha i3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02210,896,779 - 210,934,733 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,896,656 - 210,934,749 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,366,027 - 230,403,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,668,275 - 203,706,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12203,631,028 - 203,668,983 (-)NCBI
Celera2188,388,024 - 188,425,978 (-)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21390.8RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gnai3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2714
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.