Gene: Gpc3 (glypican 3) Rattus norvegicus
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Symbol: Gpc3
Name: glypican 3
Description: Predicted to have peptidyl-dipeptidase inhibitor activity; involved in negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway; localizes to the anchored component of plasma membrane; orthologous to human GPC3 (glypican 3); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; INTERACTS WITH (RS)-amphetamine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: defective in Simpson-Golabi-Behmel overgrowth syndrome; glypican-3; intestinal protein OCI-5; MGC93606; OCI-5; proteoglycan GPC3
Orthologs:
Homo sapiens (human) : GPC3 (glypican 3)  HGNC  Alliance
Mus musculus (house mouse) : Gpc3 (glypican 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpc3 (glypican 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GPC3 (glypican 3)
Canis lupus familiaris (dog) : GPC3 (glypican 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpc3 (glypican 3)
Sus scrofa (pig) : GPC3 (glypican 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,192,115 - 139,560,649 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X139,264,617 - 139,634,082 (-)NCBI
CeleraX130,783,069 - 131,149,772 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gpc3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2725
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.