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Gene: Tle5 (TLE family member 5, transcriptional modulator) Rattus norvegicus
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Symbol: Tle5
Name: TLE family member 5, transcriptional modulator
Description: Predicted to have identical protein binding activity; repressing transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of anoikis; and response to interleukin-1. Localizes to the nucleus. Orthologous to human TLE5 (TLE family member 5, transcriptional modulator); INTERACTS WITH bisphenol A; ethanol; nefazodone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Aes; amino enhancer of split; amino-terminal enhancer of split; Grg; Grg-5; groucho-related protein 5; MGC124620; R-esp1; related to Drosophila groucho; related to Drosophila groucho gene; TLE family member 5
Orthologs:
Homo sapiens (human) : TLE5 (TLE family member 5, transcriptional modulator)  HGNC  Alliance
Mus musculus (house mouse) : Tle5 (TLE family member 5, transcriptional modulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tle5 (TLE family member 5, transcriptional modulator)
Pan paniscus (bonobo/pygmy chimpanzee) : TLE5 (TLE family member 5, transcriptional modulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tle5 (TLE family member 5, transcriptional modulator)
Sus scrofa (pig) : TLE5 (TLE family member 5, transcriptional modulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0711,012,843 - 11,018,156 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,013,681 - 11,018,160 (-)Ensembl
Rnor_5.0711,180,239 - 11,187,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,616,545 - 9,621,697 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.179,616,544 - 9,621,684 (-)NCBI
Celera76,334,418 - 6,339,570 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tle5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2731
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.