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Gene: Grm5 (glutamate metabotropic receptor 5) Rattus norvegicus
Symbol: Grm5
Name: glutamate metabotropic receptor 5
Description: Exhibits A2A adenosine receptor binding activity; glutamate receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of protein kinase activity; and trans-synaptic signaling. Localizes to several cellular components, including astrocyte projection; dendrite; and postsynaptic membrane. Orthologous to human GRM5 (glutamate metabotropic receptor 5); PARTICIPATES IN calcium/calcium-mediated signaling pathway; glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-3,5-dihydroxyphenylglycine; (S)-amphetamine.
Type: protein-coding
Also known as: glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; mGlur5
Homo sapiens (human) : GRM5 (glutamate metabotropic receptor 5)  HGNC  Alliance
Mus musculus (house mouse) : Grm5 (glutamate receptor, metabotropic 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm5 (glutamate metabotropic receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GRM5 (glutamate metabotropic receptor 5)
Canis lupus familiaris (dog) : GRM5 (glutamate metabotropic receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm5 (glutamate metabotropic receptor 5)
Sus scrofa (pig) : GRM5 (glutamate metabotropic receptor 5)
Chlorocebus sabaeus (African green monkey) : GRM5 (glutamate metabotropic receptor 5)
Heterocephalus glaber (naked mole-rat) : Grm5 (glutamate metabotropic receptor 5)
more info ...
Allele / Splice: Grm5em1Sage  
Genetic Models: SD-Grm5em1Sage
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01151,207,846 - 151,785,038 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,439,409 - 151,783,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,517,676 - 158,096,869 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,857,225 - 144,477,419 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11143,935,630 - 144,555,825 (+)NCBI
Celera1139,643,467 - 140,193,665 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grm5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2746
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.