Gene: Hmgb1 (high mobility group box 1) Rattus norvegicus
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Symbol: Hmgb1
Name: high mobility group box 1
Description: Exhibits several functions, including glycolipid binding activity, nucleic acid binding activity, and signaling receptor binding activity; involved in several processes, including defense response to other organism, generation of neurons, and positive regulation of cytokine production; localizes to several cellular components, including the cytosol, extracellular space, and membrane raft; used to study congestive heart failure, malignant glioma, myocardial infarction, pulmonary hypertension, and sciatic neuropathy; biomarker of artery disease (multiple), bilirubin metabolic disorder, colon adenocarcinoma, hydrocephalus, and periodontitis; orthologous to human HMGB1 (high mobility group box 1); PARTICIPATES IN cisplatin drug pathway; mismatch repair pathway; base excision repair pathway; INTERACTS WITH (R)-rosmarinic acid; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ac2-008; Ac2-008-like; amphoterin; heparin-binding protein p30; high mobility group 1; high mobility group protein 1; high mobility group protein B1; HMG-1; Hmg1; LOC100361707; MGC93598; MGC93599
Orthologs:
Homo sapiens (human) : HMGB1 (high mobility group box 1)  HGNC  Alliance
Mus musculus (house mouse) : Hmgb1 (high mobility group box 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgb1 (high mobility group box 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGB1 (high mobility group box 1)
Canis lupus familiaris (dog) : HMGB1 (high mobility group box 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgb1 (high mobility group box 1)
Sus scrofa (pig) : HMGB1 (high mobility group box 1)
more info ...
Related Pseudogenes: Hmgb1-ps1   Hmgb1-ps2   Hmgb1-ps3   Hmgb1-ps4   LOC690117  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0127,082,529 - 7,090,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0129,177,615 - 9,178,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11637,462,230 - 37,464,451 (+)NCBI
Celera127,732,744 - 7,737,689 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hmgb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2802
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-05-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.