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Gene: Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) Rattus norvegicus
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Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Description: Exhibits hydroxymethylglutaryl-CoA reductase activity; identical protein binding activity; and protein phosphatase 2A binding activity. Involved in several processes, including lipid homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Localizes to intracellular membrane-bounded organelle. Used to study Wilson disease; drug-induced hepatitis; end stage renal failure; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of non-alcoholic fatty liver disease and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase); PARTICIPATES IN bile acid signaling pathway; metabolic syndrome X pathway; alendronate pharmacodynamics pathway; INTERACTS WITH (+)-alpha-tocopherol; (25R)-cholest-5-ene-3beta,26-diol; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMG-CoA reductase
Orthologs:
Homo sapiens (human) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)  HGNC  Alliance
Mus musculus (house mouse) : Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Canis lupus familiaris (dog) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
Sus scrofa (pig) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Chlorocebus sabaeus (African green monkey) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Heterocephalus glaber (naked mole-rat) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
Celera224,043,814 - 24,065,183 (-)NCBICelera
Cytogenetic Map2q12NCBI
RH 3.4 Map213.3RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hmgcr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2803
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.