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Gene: Hnf4a (hepatocyte nuclear factor 4, alpha) Rattus norvegicus
Symbol: Hnf4a
Name: hepatocyte nuclear factor 4, alpha
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; long-chain fatty acid binding activity; and long-chain fatty acyl-CoA binding activity. Involved in several processes, including hepatocyte differentiation; negative regulation of peptidyl-tyrosine phosphorylation; and regulation of cellular biosynthetic process. Localizes to cytoplasm and nucleus. Biomarker of hepatocellular carcinoma and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi syndrome; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha transcription factor 4; hepatic nuclear factor 4; hepatic nuclear factor 4 (alpha transcription factor 4); hepatic nuclear factor 4, alpha; hepatocyte nuclear factor 4 alpha 3; hepatocyte nuclear factor 4 alpha 9; hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Hnf4; Hnf4alpha; HNF4alpha10; HNF4alpha11; HNF4alpha12; nuclear receptor subfamily 2 group A member 1; TCF-14; Tcf4; transcription factor 14; transcription factor HNF-4
Homo sapiens (human) : HNF4A (hepatocyte nuclear factor 4 alpha)  HGNC  Alliance
Mus musculus (house mouse) : Hnf4a (hepatic nuclear factor 4, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF4A (hepatocyte nuclear factor 4 alpha)
Canis lupus familiaris (dog) : HNF4A (hepatocyte nuclear factor 4 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Sus scrofa (pig) : HNF4A (hepatocyte nuclear factor 4 alpha)
Chlorocebus sabaeus (African green monkey) : HNF4A (hepatocyte nuclear factor 4 alpha)
Heterocephalus glaber (naked mole-rat) : Hnf4a (hepatocyte nuclear factor 4 alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03159,902,441 - 159,965,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,902,441 - 159,965,003 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,093,091 - 166,155,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,459,863 - 154,482,825 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,365,898 - 154,388,861 (+)NCBI
Celera3150,839,856 - 150,901,426 (+)NCBICelera
Cytogenetic Map3q42NCBI
RH 3.4 Map31376.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hnf4a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2810
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.