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Gene: Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2) Rattus norvegicus
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
CRRD ID: 2835
Description: Exhibits 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NAD binding activity; and steroid binding activity. Involved in several processes, including glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; and response to food. Localizes to cytoplasm and intracellular membrane-bounded organelle. Biomarker of hypertension; myocardial infarction; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,4-dithiothreitol.
Type: protein-coding
Also known as: 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; corticosteroid 11-beta-dehydrogenase isozyme 2; Hydroxysteroid dehydrogenase 11 beta type 2; Hydroxysteroid dehydrogenase, 11 beta type 2; MGC93528; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Homo sapiens (human) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)  HGNC  Alliance
Mus musculus (house mouse) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Canis lupus familiaris (dog) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Sus scrofa (pig) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Chlorocebus sabaeus (African green monkey) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Heterocephalus glaber (naked mole-rat) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
more info ...
Allele / Splice: Hsd11b2em1Jmul  
Genetic Models: F344-Hsd11b2em1Jmul-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01937,476,083 - 37,481,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,476,095 - 37,481,307 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,341,841 - 48,347,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,336,342 - 35,341,585 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,341,222 - 35,346,466 (+)NCBI
Celera1932,826,007 - 32,831,250 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hsd11b2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2835
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.