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Gene: Hspa1b (heat shock protein family A (Hsp70) member 1B) Rattus norvegicus
Symbol: Hspa1b
Name: heat shock protein family A (Hsp70) member 1B
Description: Exhibits NF-kappaB binding activity and protease binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of vasoconstriction; and positive regulation of T cell mediated cytotoxicity. Localizes to several cellular components, including apical plasma membrane; basolateral plasma membrane; and membrane raft. Predicted to colocalize with COP9 signalosome. Human ortholog(s) of this gene implicated in several diseases, including CAKUT; brain ischemia; obesity; toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kD protein 1B; heat shock protein 1B; Heat shock protein 70-1; heat shock protein family A member 1B; Hsp70-1; HSP70-1/HSP70-2; Hsp70-2; HSP70.1; HSP70.1/2; HSP70.1/HSP70.2; HSP70.2; HSP72; Hspa1; Hspa1a; Hspa2
Homo sapiens (human) : HSPA1B (heat shock protein family A (Hsp70) member 1B)  HGNC  Alliance
Mus musculus (house mouse) : Hspa1b (heat shock protein 1B)  MGI  Alliance
Canis lupus familiaris (dog) : HSP70 (heat shock protein 70)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa1b (heat shock protein family A (Hsp70) member 1B)
Chlorocebus sabaeus (African green monkey) : HSPA1B (heat shock protein family A (Hsp70) member 1B)
more info ...
Is Marker For: Strains:   SHR-Hspa1em1Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,877,638 - 4,880,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,029,038 - 7,033,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,802,576 - 4,804,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,955,274 - 3,957,748 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,167,705 - 4,171,749 (-)NCBICelera
Cytogenetic Map20p12NCBI
RH 3.4 Map20 RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hspa1b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2840
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.