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Gene: Iapp (islet amyloid polypeptide) Rattus norvegicus
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Symbol: Iapp
Name: islet amyloid polypeptide
Description: Predicted to have identical protein binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; and eating behavior. Predicted to localize to the extracellular space; inclusion body; and neuronal cell body. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; 3,3',5,5'-tetrabromobisphenol A; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: amylin; DAP; diabetes-associated peptide
Orthologs:
Homo sapiens (human) : IAPP (islet amyloid polypeptide)  HGNC  Alliance
Mus musculus (house mouse) : Iapp (islet amyloid polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iapp (islet amyloid polypeptide)
Pan paniscus (bonobo/pygmy chimpanzee) : IAPP (islet amyloid polypeptide)
Canis lupus familiaris (dog) : IAPP (islet amyloid polypeptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iapp (islet amyloid polypeptide)
Sus scrofa (pig) : IAPP (islet amyloid polypeptide)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)Ensembl
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
Cytogenetic Map4q44NCBI
RH 3.4 Map41043.4RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Iapp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2854
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.