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Gene: Igf1r (insulin-like growth factor 1 receptor) Rattus norvegicus
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Description: Exhibits G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Localizes to several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor); PARTICIPATES IN insulin-like growth factor signaling pathway; E-cadherin signaling pathway; endocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IGF-1 receptor; IGF-I receptor; IGFIRC; Igfr1; insulin-like growth factor I receptor; JTK13; type-I IGF receptor
Homo sapiens (human) : IGF1R (insulin like growth factor 1 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Igf1r (insulin-like growth factor I receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf1r (insulin like growth factor 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF1R (insulin like growth factor 1 receptor)
Canis lupus familiaris (dog) : IGF1R (insulin like growth factor 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf1r (insulin like growth factor 1 receptor)
Sus scrofa (pig) : IGF1R (insulin like growth factor 1 receptor)
Chlorocebus sabaeus (African green monkey) : IGF1R (insulin like growth factor 1 receptor)
Heterocephalus glaber (naked mole-rat) : Igf1r (insulin like growth factor 1 receptor)
more info ...
Is Marker For: Strains:   SHRSP.WKY-(Igf1r-D1Rat36)/IzmTkyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Celera1113,751,636 - 114,029,884 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Igf1r
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2869
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.