Gene: Igf1r (insulin-like growth factor 1 receptor) Rattus norvegicus
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Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Description: Exhibits G-protein alpha-subunit binding activity, insulin receptor substrate binding activity, and insulin-like growth factor-activated receptor activity; involved in several processes, including cellular response to hormone stimulus, negative regulation of apoptotic process, and nervous system development; localizes to several cellular components, including the T-tubule, axon, and caveola; used to study Alzheimer's disease, Parkinson's disease, and prostate adenocarcinoma; biomarker of several diseases, including acute kidney failure, artery disease (multiple), carcinoma (multiple), diabetes mellitus (multiple), and neurodegenerative disease (multiple); orthologous to human IGF1R (insulin like growth factor 1 receptor); PARTICIPATES IN insulin-like growth factor signaling pathway; E-cadherin signaling pathway; endocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IGF-1 receptor; IGF-I receptor; IGFIRC; Igfr1; insulin-like growth factor I receptor; JTK13; type-I IGF receptor
Orthologs:
Homo sapiens (human) : IGF1R (insulin like growth factor 1 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Igf1r (insulin-like growth factor I receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf1r (insulin like growth factor 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF1R (insulin like growth factor 1 receptor)
Canis lupus familiaris (dog) : IGF1R (insulin like growth factor 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf1r (insulin like growth factor 1 receptor)
Sus scrofa (pig) : IGF1R (insulin like growth factor 1 receptor)
more info ...
Is Marker For: Strains:   SHRSP.WKY-(Igf1r-D1Rat36)/IzmTkyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Celera1113,751,636 - 114,029,884 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Igf1r
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2869
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.