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Gene: Igf2r (insulin-like growth factor 2 receptor) Rattus norvegicus
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Symbol: Igf2r
Name: insulin-like growth factor 2 receptor
Description: Exhibits several functions, including G-protein alpha-subunit binding activity; enzyme binding activity; and insulin-like growth factor II binding activity. Involved in several processes, including animal organ development; response to retinoic acid; and spermatogenesis. Localizes to the cytoplasm; extracellular space; and plasma membrane. Colocalizes with the trans-Golgi network. Used to study lung adenocarcinoma. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cation-independent mannose-6-phosphate receptor; IGF-IIR; Igfr2
Orthologs:
Homo sapiens (human) : IGF2R (insulin like growth factor 2 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Igf2r (insulin-like growth factor 2 receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf2r (insulin like growth factor 2 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF2R (insulin like growth factor 2 receptor)
Canis lupus familiaris (dog) : IGF2R (insulin like growth factor 2 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf2r (insulin like growth factor 2 receptor)
Sus scrofa (pig) : IGF2R (insulin like growth factor 2 receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0148,176,095 - 48,264,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0151,488,767 - 51,577,141 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,253,273 - 42,341,646 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,256,217 - 42,344,589 (+)NCBI
Celera143,778,518 - 43,867,238 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Igf2r
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2871
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.