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Gene: Il1a (interleukin 1 alpha) Rattus norvegicus
Symbol: Il1a
Name: interleukin 1 alpha
Description: Predicted to have copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of cell communication. Localizes to several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); otitis media; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; hematologic cancer (multiple); lung disease (multiple); and rheumatoid arthritis (multiple). Orthologous to human IL1A (interleukin 1 alpha); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (R)-lipoic acid; (R)-mevalonic acid.
Type: protein-coding
Also known as: IL-1 alpha; IL-1F1; interleukin-1 alpha
Homo sapiens (human) : IL1A (interleukin 1 alpha)  HGNC  Alliance
Mus musculus (house mouse) : Il1a (interleukin 1 alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1a (interleukin 1 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL1A (interleukin 1 alpha)
Canis lupus familiaris (dog) : IL1A (interleukin 1 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1a (interleukin 1 alpha)
Sus scrofa (pig) : IL1A (interleukin 1 alpha)
Chlorocebus sabaeus (African green monkey) : IL1A (interleukin 1 alpha)
Heterocephalus glaber (naked mole-rat) : Il1a (interleukin 1 alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Il1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2890
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.